桑志培 男 理学博士  副教授  硕士生导师

  邮箱：[email protected]

    2015年博士毕业于四川大学华西药学院，从事抗阿尔茨海默症药物的研究；2019年5月赴新加坡南洋理工大学生物科学学院从事博士后研究，主要聚焦于新型多肽环化/连接酶的发展；2021年11月于上海中医药大学交叉科学研究院从事在职博士后研究，主要聚焦于hCES2A抑制剂的开发及应用。于2022年8月通过高层次人才引进到海南大学药学院工作至今。

  1.教育背景

  2021.11-至今 上海中医药大学，交叉科学研究院，在职博士后，合作导师：葛广波教授

  2019-05至2020-06，新加坡南洋理工大学，生物科学学院，博士后，合作导师：James P Tam教授（新加坡国家科学院院士）

  2010-09至2015-06，四川大学华西药学院，药物化学，硕博连读，导师：邓勇教授

  2006-09至2010-07，贵州医科大学，药学，学士

2.教学情况

主讲药物化学

3.科研情况

目前研究方向聚焦于“基于靶向丝氨酸水解酶和/或PDEs的全新药物设计、结构优化、成药性评价及作用机制研究”。目前已在国内外重要学术期刊Eur J Med Chem, Bioorg Chem，J Agric Food Chem等发表论文80余篇，以第一和/或通讯作者发表论文38篇，获得具有自主知识产权的授权发明专利23项，实用新型专利5项。主持河南省自然科学基金、中国博士后科学基金面上项目、河南省高层次人才国际化培养项目、河南省科技攻关项目、河南省高等学校重点科研项目等10余项；参与国家自然科学基金青年项目、河南省科技攻关项目、河南省高等学校重点科研项目等5项。目前已有多个项目分别针对阿尔茨海默症、血管痴呆、脑卒中、肿瘤等疾病的研究取得重大进展。

4.研究领域

1）药物分子设计、结构和成药性优化及作用机制研究

2）靶向PDE药物开发

3）生物活性肽研究

5.代表性项目

1）海南大学科研启动基金项目，靶向PDE4的新型抗AD药物研究，2022.09-2026.12，主持

2）中国博士后科学基金第71批面上项目二等资助，“人羧酸酯酶2A特异性共价抑制剂的设计研发、成药性优化及药效学研究，2022M712153”，2022.01-2023.12，主持。

3）贵州医科大学 省部共建药用植物功效与利用国家重点实验室开放课题，“杜仲中新型多肽的制备及其活性评价，No.FAMP202107K”，2022.01-2023.12，主持。

4）贵州医科大学 化学合成药物研发利用工程技术研究中心开放课题，“具有诱导自噬作用的cGN14细胞穿膜环肽的设计、合成及其抗AD活性研究”，2021.08-2022.07，主持

5）横向项目，“复方藤梨汤对U251胶质瘤细胞周期、凋亡及wnt信号传导通路表达的影响”，2021.05-2022.05，主持。

6）横向项目，“利用LCMS检测小鼠血药浓度”，2021.06-2022.05，主持。

7）河南省科技厅科技攻关项目，“裕丹参中新型多肽的发现及药理活性研究，2121023111000”，2021.01-2022.12，主持

8）2020年河南省高等学校重点科研项目，“基于脑靶向的新型高选择性BuChE抑制剂的设计、合成及其抗阿尔茨海默病活性研究，20A350006”，2020.01-2021.12，主持

9）2019年河南省高层次人才国际化培养项目，“口服植物活性肽的研究, 17”，2019.05-2020.06，主持

10）河南省自然科学基金，“基于Aβ/AChE双靶点策略的查尔酮衍生物的设计、合成与抗阿尔茨海默病活性研究，162300410103”，2016.01-2017.12，主持

11）2017年河南省高等学校重点科研项目计划，“新型多靶点抑制剂的设计、合成及抗阿尔茨海默症活性研究，17B350002”，2017.01-2018.12，主持

12）国家自然科学基金青年项目，“LncRNA-C2dat2促进脑缺血再灌注后 CaMKⅡ磷酸化激活P38信号通路诱导神经元凋亡的功能及机制研究，81701185”，2018-01至2020-12，参与

13）河南省科技厅科技攻关项目，“侧链含二硫键的可交联聚噻吩光电材料的设计及其电致变色应用研究，202102210033”，2020.01-2021.12，参与

14）2018年河南省高等学校重点科研项目计划，“光敏感核可逆交联聚碳酸酯胶束的制备及其在药物控释中的应用，18A150040”，2018.01-2019.12, 参与

15）2018年河南省高等学校重点科研项目计划，“脑缺血后lncRNA-C2dat2激活CaMKⅡ/p38信号通路调控神经元自噬推动凋亡进程的功能及机制研究，18A320003”，2018.01-2019.12，参与

16）河南省科技厅科技攻关项目，“荔枝草对D-半乳糖胺肝损伤的保护作用及机制研究，172102310552”，2017.01-2018.12，参与

17）2017年河南省高等学校重点科研项目计划，“鱼腥草中抗癌活性化学成分研究，17A350011”，2017.01-2018.12，参与

6.代表性成果

本人近年来主要从事小分子化学药物抗阿尔茨海默病活性研究、植物源生物活性肽的研究及中药活性小分子研究。截止目前，已发表SCI论文80余篇，以第一和/或通讯作者发表论文38篇，其中，European Journal of Medicinal Chemistry 12篇；Bioorganic Chemistry 3篇；Food & Function 1篇；Journal of Enzyme Inhibition and Medicinal Chemistry 3篇；Frontiers in Aging Neuroscience 1篇；ACS Chemical Neuroscience 1篇；Bioorganic & Medicinal Chemistry 2篇；RSC Advances 1篇；Bioorganic & Medicinal Chemistry Letters 4篇；Chemical Biology & Drug Design 1篇；Letters in Drug Design & Discovery 2篇；Medicinal Chemistry Research 3篇；中国药学杂志、药学进展、中国药科大学学报、华西药学杂志各1篇综述。获得具有自主知识产权的授权发明专利23项，实用新型专利5项。

2017年至今发表代表性文章（#表示为共同第一，*表示为通讯作者）

1）Sang Zhipei#,*, Bai Ping#, Ban Yujuan#, Wang Kerne#, Wu Anguo, Mi Jing, Hu Jiaqi, Xu Rui, Zhu Gaofeng, Wang Jianta, Zhang Jiquan, Wang Changning*, Tan Zhenghuai*, Tang Lei*. Novel donepezil-chalcone-rivastigmine hybrids as potential multifunctional anti-Alzheimer's agents: Design, synthesis, in vitro biological evaluation, in vivo and in silico studies. Bioorganic Chemistry. 2022, 127: 106007. (IF = 5.307)

2）Liu Chan#, Sang Zhipei#, Pan Hong, Wu Qin, Qiu Yu*, Shi Jingshan*. A novel multifunctional 5,6-dimethoxy-indanone-chalcone-carbamate hybrids alleviates cognitive decline in Alzheimer's disease by dual inhibition of acetylcholinesterase and inflammation. Frontiers in Aging Neuroscience. 2022, 14: 922650. (IF = 5.702)

3）Zhou XG, Qiu WQ, Yu L, Pan R, Teng JF, Sang ZP, Law BY, Zhao Y, Zhang L, Yan L, Tang Y, Sun XL, Wong VKW, Yu CL, Wu JM, Qin DL, Wu AG. Targeting microglial autophagic degradation of the NLRP3 inflammasome for identification of thonningianin A in Alzheimer's disease. Inflammation Regeneration. 2022, 42(1): 25. (IF = 10.426)

4）Ma Qinge, Guan Yang, Sang Zhipei*, Dong Jianghong, Wei Rongrui*. Isolation and characterization of auronlignan derivatives with hepatoprotective and hypolipidemic activities from the fruits of Hippophae rhamnoides L. Food & Function. 2022, 13(14):7750-7761. (IF = 6.317)

5）Sang Zhipei#,*, Wang Keren#, Dong Jianghong#, Tang Lei*. Alzheimer's disease: Updated multi-targets therapeutics are in clinical and in progress. European Journal of Medicinal Chemistry. 2022, 238: 114464. (IF = 7.088)

6）Zhu Gaofeng#, Bai Ping#, Wang Keren#, Mi Jing, Yang Jing, Hu Jiaqi, Ban Yujuan, Xu Rui, Chen Rui, Wang Changning*, Tang Lei*, Sang Zhipei*. Design, synthesis, and evaluation of novel O-alkyl ferulamide derivatives as multifunctional ligands for treating Alzheimer's disease. Journal of Enzyme Inhibition and Medicinal Chemistry. 2022, 37(1): 1375-1388. (IF = 5.756)

7）Yang Jing#, Zhou Yi#, Ban Yujuan#, Mi Jing, HeYing, Li Xinjuan, Liu Zhengwei, Wang Keren, Zhu Gaofeng, Liu Wenmin, Tan Zhenghuai*, Sang Zhipei*. Development of naringenin-O-alkylamine derivatives as multifunctional agents for the treatment of Alzheimer’s disease. Journal of Enzyme Inhibition and Medicinal Chemistry. 2022, 37(1): 792-816. (IF = 5.756)

8）Mi Jing#, He Ying#, Yang Jing, Zhou Yi, Zhu Gaofeng, Wu Aaguo*, Liu Wenmin*, Sang Zhipei*. Development of naringenin-O-carbamate derivatives as multi-target-directed liagnds for the treatment of Alzheimer's disease. Bioorg Med Chem Lett. 2022, 60: 128574. (IF = 2.940)

9）Sang Zhipei, Song Qing, Cao Zhongcheng, Deng Yong, Zhang Li*. Design, synthesis, and evaluation of chalcone-Vitamin E-donepezil hybrids as multi-target-directed ligands for the treatment of Alzheimer's disease. Journal of Enzyme Inhibition and Medicinal Chemistry. 2022, 37(1): 69-85. (IF = 5.756)

10）Wang Keren#, Shi Jian#, Zhou Yi, He Ying, Mi Jing, Yang Jing, Liu Shuang, Tang Xiangcheng, Liu Wenmin, Tan Zhenghuai*, Sang Zhipei*. Design, synthesis and evaluation of cinnamic acid hybrids as multi-target-directed agents for the treatment of Alzheimer’s disease. Bioorganic Chemistry. 2021, 112：104879. (IF = 5.307)

11）Sang Zhipei*,#, Song Qing, Cao Zhongcheng, Deng Yong, Tan Zhenghuai, Zhang Li*. Design, synthesis and evaluation of novel dimethylamino chalcone-O-alkylamines derivatives as potential multifunctional agents against Alzheimer's disease.European Journal of Medicinal Chemistry. 2021, 216: 113310. (IF = 7.088)

12）Sang Zhipei*,#, Shi Jian#, Zhou Yi, Wang Keren, Zhao Yiyang, Li Qingfeng, Qiao Zhanpin, Wu Anguo*, Tan Zhenghuai*, Liu Wenmin*. Development of genistein-O-alkylamines derivatives as multifunctional agents for the treatment of Alzheimer's disease. Bioorganic Chemistry. 2021, 107: 104602. (IF = 5.307)

13）Sang Zhipei*,#, Wang Keren#, Bai Ping#, Wu Anguo, Shi Jian, Wenmin Liu, Zhu Gaofeng, Wang Yiling, Lan Yu, Chen Zude, Zhao Yiyang, Zhanpin Qiao, Wang Changning*, Tan Zhenghuai*. Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry, 2020, 194: 112265. (IF = 6.514)

14）Sang Zhipei*,#, Wang Keren#, Shi Jian, Wenmin Liu, Cheng xinfeng, Zhu Gaofeng, Wang Yiling, Zhao Yiyang, Zhanpin Qiao, Wu Anguo*, Tan Zhenghuai*. The development of advanced structural framework as multi-target-directed ligands for the treatment of Alzheimer’s disease. European Journal of Medicinal Chemistry, 2020, 192: 112180. (IF = 6.514)

15）Sang Zhipei*,#, Wang Keren#, Shi Jian, Cheng xinfeng, Zhu Gaofeng, Wei Rongrui, Ma Qinge, Yu Lintao, Zhao Yiyang, Tan Zhenghuai*, Liu Wenmin*. Apigenin-rivastigmine hybrids as multi-target-directed ligands for the treatment of Alzheimer’s disease. European Journal of Medicinal Chemistry, 2020, 187: 111958. (IF = 6.514)

16）Sang Zhipei*,#, Wang Keren#, Zhang Pengfei, Shi Jian, Liu Wenmin*, Tan Zhenghuai*. Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer’s disease. European Journal of Medicinal Chemistry, 2019, 180: 238-252. (IF = 5.573)

17）Sang Zhipei*,#, Wang Keren#, Shi Jian, Liu Wenmin*, Tan Zhenghuai*. Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer’s disease. European Journal of Medicinal Chemistry, 2019, 178: 726-739. (IF = 5.573)

18）Bai Ping#, Wang Keren#, Zhang Pengfei#, Shi Jian, Cheng Xinfeng, Zhang Qi, Zheng Cheng, Yang Jian, Lu Xiaoxia*, Sang Zhipei*. Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer’s disease. European Journal of Medicinal Chemistry, 2019, 183: 111737. ( IF = 5.573)

19）Sang Zhipei*,#, Wang Keren#, Han Xue, Cao Mengxiao, Tan Zhenghuai*, Liu Wenmin*. Design, synthesis and evaluation of novel ferulic acid derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.ACS Chemical Neuroscience. 2019, 10(2): 1008-1024. (IF = 4.486)

20）Zhu Gaofeng#, Wang Keren#, Shi Jian, Zhang Pengfei,Yang Dan, Fan Xiaotian, Zhang Ziyi,  Liu Wenmin, Sang Zhipei*. The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer’s disease. Bioorganic & Medicinal Chemistry Letters. 2019, 29 (19): 126625. (IF = 2.572)

21）Sang Zhipei*, Pan Wanli, Wang Keren, Ma Qinge, Yu Lintao, Yang Yan, Bai Ping, Leng Chaoliang, Xu Qian, Li Xiaoqing, Tan Zhenghuai, Liu Wenmin*. Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivativesas potential multifunctional agents for the treatment of Alzheimer’s disease. European Journal of Medicinal Chemistry, 2017, 130: 379-392. (IF = 4.816)

22）Sang Zhipei #, Qiang Xiaoming #, Li Yan, Xu Rui, Xu Zhongcheng, Song Qing, Wang Ting,  Zhang Xiaoyu, Liu Hongyan, Tan Zhenghuai*, Deng Yong*. Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry, 2017, 135: 307-323. (IF = 4.816)

23）Sang Zhipei*, Pan Wanli, Wang Keren, Ma Qinge, Yu Lintao, Liu Wenmin*. Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer’s disease. Bioorganic & Medicinal Chemistry. 2017, 25 (12): 3006-3017. (IF = 2.881)

24）Sang Zhipei*, Wang Keren, Wang Huifang, Wang Huijuan, Ma Qianwen, Han Xue, Ye Mengyao, Yu Lintao, Liu Wenmin*. Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl) phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease. Bioorganic & Medicinal Chemistry Letters. 2017, 27 (22): 5046-5052. (IF = 2.442)

25）Sang Zhipei*, Wang Keren, Wang Huifang, Yu Lintao, Wang Huijuan, Ma Qianwen, Ye Mengyao, Han Xue, Liu Wenmin*. Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease. Bioorganic & Medicinal Chemistry Letters. 2017, 27 (22): 5053-5059. (IF = 2.442)

26）Ma QG, Tang Y, Sang ZP, Dong JH, Wei RR. Structurally diverse biflavonoids from the fruits of Citrus medica L. var. sarcodactylis Swingle and their hypolipidemic and immunosuppressive activities. Bioorg Chem. 2021, 117: 105450. (IF = 5.307)

27）Ma QG, Wei RR, Yang M, Huang XY, Wang F, Dong JH, Sang ZP. Isolation and characterization of neolignan derivatives with hepatoprotective and neuroprotective activities from the fruits of Citrus medica L. var. Sarcodactylis Swingle. Bioorg Chem. 2021, 107: 104622. (IF = 5.307)

28)Ma QG, Wei RR, Shang DL, Sang ZP, Dong JH. Structurally Diverse Flavonolignans with Immunosuppressive and Neuroprotective Activities from the Fruits of Hippophae rhamnoides L. J Agric Food Chem. 2020, 68(24): 6564-6575. (IF = 5.279)

29)Wei R, Ma Q, Zhong G, He J, Sang Z.Isolation and characterization of flavonoid derivatives with anti-prostate cancer and hepatoprotective activities from the flowers of Hosta plantaginea (Lam.) Aschers. J Ethnopharmacol. 2020, 253: 112685. (IF = 4.36)

30)Ma Q, Wei R, Sang Z, Dong J.Structural characterization, neuroprotective and hepatoprotective activities of flavonoids from the bulbs of Heleocharis dulcis. Bioorg Chem. 2020, 96: 103630. (IF = 5.275)

31)Ma Q, Wei R, Yang M, Huang X, Zhong G, Sang Z, Dong J, Shu J, Liu J, Zhang R, Yang J, Wang A, Ji T, Su Y.Structures and biological evaluation of phenylpropanoid derivatives from Murraya koenigii. Bioorg Chem. 2019, 86: 159-165 (IF = 4.831)

2016年之前发表代表性文章

1)Wanli Pan, Ke Hu, Ping Bai, Lintao Yu, Qinge Ma, Tao Li, Xu Zhang, Chaozhong Chen, Kelin Peng, Wenmin Liu*, Zhipei Sang *. Design, synthesis and evaluation of novel ferulic acid-memoquin hybrids as potential multifunctional agents for the treatment of Alzheimer’s disease. Bioorganic & Medicinal Chemistry Letters. 2016, 26(10): 2539-2543. (IF = 2.454)

2)Zhipei Sang, Xiaoming Qiang, Yan Li, Wen Yuan, Qiang Liu, Wei Ang, Yikun Shi, Youfu Luo, Zhenhuai Tan*, Yong Deng*, Design, synthesis and evaluation of scutellarein-O-alkylamines as potent multifunctional anti-Alzheimer’s disease agents for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry, 2015, 94: 348-366. (IF = 3.902)

3)Zhipei Sang, Xiaoming Qiang, Yan Li, Bei Wu, Hui Zhang, Minggao Zhao, Yong Deng*, Design, synthesis and biological evaluation of scutellarein carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer's disease. Chemical Biology & Drug Design, 2015, 86(5): 1168-1177. (IF = 2.485)

4)Zhipei Sang, Yan Li, Xiaoming Qiang, Ganyuan Xiao, Qiang Liu, Zhenhuai Tan*, Yong Deng*, Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometals chelating and neuroprotective properties for the treatment of Alzheimer's disease. Bioorganic & Medicinal Chemistry, 2015, 23(4): 668-680. (IF = 2.793)

5)Xiaoming Qiang#, Zhipei Sang#, Wen Yuan, Yan Li, Qiang Liu, Ping Bai, Yikun Shi, Wei Ang, Zhenhuai Tan*, Yong Deng*, Design, synthesis and evaluation of genistein-O-alkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry, 2014, 76: 314-331. (IF = 3.343)

已授权代表性发明专利

1)桑志培; 王柯人；柳文敏；时健；程新峰；于林涛. 一种2’-羟基-3苯基苯丙酮化合物及其制备方法和用途. 2022.01.07. 中国 ZL2019106197603.

2)桑志培; 王柯人; 柳文敏; 于林涛; 时健; 马倩文; 王慧娟.一种茚酮查尔酮氨基甲酸酯类化合物及其制备方法和用途. 2021.03.30. 中国ZL2019101892884.

3)桑志培; 王柯人; 柳文敏; 于林涛; 时健; 程新峰；马倩文. 一种4-氨基甲酸酯-肉桂酰胺-4-苄基哌啶类化合物及其制备方法和用途. 2020.11.03. 中国ZL2019100795872.

4)桑志培; 王柯人; 柳文敏; 程新峰; 时健; 于林涛; 冉亚文. 一种芹菜素-O-烷基胺类化合物、制备方法和应用. 2020.06.26. 中国ZL2019100960136.

5)桑志培; 柳文敏; 王柯人; 潘万里; 张胜; 程新峰. 一种N-(4-苄基哌啶基)-阿魏酰胺化合物、制备方法及其用途. 2019.06.18. 中国 ZL2017100584209

7.荣誉奖励

1)2020年度河南省教育厅科技成果奖优秀科技论文奖二等奖，河南省教育厅，教科技[2020]135号, 2020.05，第一

2)第十五届“挑战杯”河南省大学生课外学术科技作品竞赛中荣获“二等奖”两项，2021.06，第一指导教师

3)第十三届“挑战杯”河南省大学生课外学术科技作品竞赛二等奖，2017.08.10，第一指导教师

4)第八届“国药工程—东富龙杯”全国大学生制药工程设计竞赛二等奖，2018.08，第二指导教师